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Early lung cancer detection needed

When Dana Reeve, widow of actorstudies with people). Some of these
Christopher Reeve, died of lung cancer,agents are being investigated as single
the stories of her death pointed outagents; others are being tested in
that she didn't smoke. She was young,combinations of two drugs.
only 44; she had nursed her paralyzedChemoprevention trials look at possible
husband for eight years; she left aways to prevent cancer with
13-year-old son an orphan. And how couldinterventions that include drugs,
she have gotten lung cancer? She hadvitamins, diet, hormone therapy, or
never smoked.Lung cancer is oftenother agents.
preventable, and it is usually fatal.The American Cancer Society (ACS) has
Unfortunately I will also become aset aggressive challenge goals for the
victim of this disease. Not for myself,nation to decrease cancer incidence and
but a victim because I am a friend of amortality--and to improve the quality of
lung cancer person. One of my verylife of cancer survivors--by the year
dearest friends will undergo a lung2015. To address these critical goals,
operation this coming Tuesday.the ACS publishes the Nutrition and
Be cautious of any information or claimsPhysical Activity Guidelines to serve as
obtained from unmonitored sources, ina foundation for its communication,
particular the Internet. The Internetpolicy, and community strategies and
can be an empowering source ofultimately, to affect dietary and
information, but a healthcarephysical activity patterns among
professional should be consulted beforeAmericans.
making medical decisions.These guidelines, published every five
What is cancer?years, are developed by a national panel
Cancer is a disease that starts in ourof experts in cancer research,
cells. Our bodies are made up ofprevention, epidemiology, public health,
millions of cells, grouped together toand policy, and as such, they represent
form tissues or organs. Genes insidethe most current scientific evidence
each cell order it to grow, work,related to dietary and activity patterns
reproduce and die.and cancer risk. The ACS guidelines
Normally, our cells remain healthy.are consistent with guidelines from the
Sometimes a cell's instructions getAmerican Heart Association for the
mixed up and it behaves abnormally.prevention of coronary heart disease as
After a while, groups of abnormal cellswell as for general health promotion, as
can circulate in the blood or immunedefined by the Department of Health and
system, or they can form lumps orHuman Services' 2000 Dietary Guidelines
tumours.for Americans.
Tumours can be either benignIn 2006 there will be an estimated
(non-cancerous) or malignant174,470 new cases of lung cancer and an
(cancerous). Benign tumour cells stay inestimated 162,460 Americans will die
one place in the body and are notfrom the disease.
usually life-threatening.The American Cancer Society offers
Malignant tumour cells are able tosupport and hope for people diagnosed
invade the tissues around them andwith lung cancer and their families as
spread to other parts of the body.well as resources to help smokers quit
Cancerous cells that spread to other24 hours a day, 7 days a week, including
parts of the body are called metastases.its own Quitline, which since its launch
The first sign that a malignant tumourin May 2000 has provided services to
has spread is often swelling of nearbymore than 150,000 callers. For more
lymph nodes, but cancer can metastasizeinformation, call 800-ACS-2345 or visit
to almost any part of the body. It isLung cancer chemoprevention - Why does
important to find malignant tumoursit not work?From the National Cancer
early and treat them.Center.
Cancers are named after the part of theCommon wisdom is that vitamin in fruits
body where they start. For example,and vegetables prevent cancer. However,
cancer that starts in the colon buttrials of supplementing vitamins like
spreads to the liver is called colonvitamin A analogues (retinoids:
cancer with liver metastases.beta-carotene, retinol, retinyl
There are four main types of lungpalmitate, or isotretinoin) or vitamin E
cancer: small cell lung cancer, squamous(alpha-tocopherol), did not prevent lung
cell carcinoma, large cell carcinoma andcancer in smokers. Randomised trials in
adenocarcinoma. Tobacco smoking isall the three settings: primary (healthy
strongly linked to the first three buthigh-risk e.g. smokers), secondary
only weakly linked to adenocarcinoma.(pre-malignant lesions), and tertiary
However, this type of lung cancer has(prevention of second primary tumours in
been linked to the use of low-tarpreviously treated patients), have
cigarettes.produced negative results (either
The best means of prevention is to neverneutral or harmful).
start smoking or using chewing tobacco,Chemoprevention trials were prompted by
or to stop using tobacco products. Arelationship between diet and lung
healthy diet is an important part ofcancer. Diet rich in foliage vitamins
prevention.was protective against lung cancer - as
The outlook varies by cell type anddemonstrated in a recent Dutch study of
stage of the disease. In general, the939 patients. Similarly, higher blood
prognosis is better for squamous celllevel of ß-carotene is linked to a
cancers than for adenocarcinomas. Earlylower risk of lung cancer. Nonetheless,
detection is key to better chances ofintervention trials failed to show a
survival.reduced risk in lung cancer by consuming
According to the American Lungß-carotene. A phase III trial, the
Association, 87 percent of lung cancerAlpha-Tocopherol, Beta-Carotene (ATBC)
cases are caused by smoking. Another 12[beta-carotene (20 mg/d),
percent are linked to radon exposure.alpha-tocopherol (50mg/d)] indicated
Only 15 percent of people diagnosed withsignificant increases in lung cancer
the disease will still be alive fiveincidence (18%) and no effect on lung
years after the diagnosis; 60 percentcancer mortality (risk ratio, 0.99).
die within the first year. What isAnother study, CARET, had a 28% increase
Chemoprevention? For individuals whoin lung cancer with vitamin treatment.
demonstrate the greatest risk,Similarly, in both Euro-scan and the
researchers are currently conductingUS-Lung Intergroup Trial (both testing
several new trials to test the use ofretinoids in tertiary prevention),
natural and synthetic substances toresults were neutral.
prevent development of the disease. ThisDisclaimer: please. Any information is
new research has been coined,for general entertainment and
chemoprevention.educational purposes only, and should
The National Cancer Institute's (NCI)not be construed as medical advice,
chemoprevention research effort startedmedical opinion, diagnosis or treatment.
in the early 1980s and has grownAny information provided by this web
considerably since that time. Currently,site is not a substitute for actual
approximately 400 compounds are beingmedical attention. Always promptly
studied as potential chemopreventiveconsult your licensed health-care
agents, mainly in laboratory research.professional for medical advice and
Over 40 of these compounds are beingtreatment.
studied in clinical trials (research



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