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Early lung cancer detection needed

When Dana Reeve, widow of actor Christopherresearch. Over 40 of these compounds are
Reeve, died of lung cancer, the stories ofbeing studied in clinical trials (research
her death pointed out that she didn't smoke.studies with people). Some of these agents
She was young, only 44; she had nursed herare being investigated as single agents;
paralyzed husband for eight years; she left aothers are being tested in combinations of
two drugs. Chemoprevention trials look at
13-year-old son an orphan. And how could shepossible ways to prevent cancer with
have gotten lung cancer? She had neverinterventions that include drugs, vitamins,
smoked.Lung cancer is often preventable, anddiet,  hormone  therapy,  or  other  agents.
it  is  usually  fatal.
The American Cancer Society (ACS) has set
Unfortunately I will also become a victim ofaggressive challenge goals for the nation to
this disease. Not for myself, but a victimdecrease cancer incidence and mortality--and
because I am a friend of a lung cancerto improve the quality of life of cancer
person. One of my very dearest friends willsurvivors--by the year 2015. To address these
undergo a lung operation this coming Tuesday.critical goals, the ACS publishes the
Nutrition and Physical Activity Guidelines to
Be cautious of any information or claimsserve as a foundation for its communication,
obtained from unmonitored sources, inpolicy, and community strategies and
particular the Internet. The Internet can beultimately, to affect dietary and physical
an empowering source of information, but aactivity  patterns  among  Americans.
healthcare professional should be consulted
before  making  medical  decisions.These guidelines, published every five years,
are developed by a national panel of experts
What  is  cancer?in cancer research, prevention, epidemiology,
public health, and policy, and as such, they
Cancer is a disease that starts in our cells.represent the most current scientific
Our bodies are made up of millions of cells,evidence related to dietary and activity
grouped together to form tissues or organs.patterns and cancer risk. The ACS
Genes inside each cell order it to grow,guidelines are consistent with guidelines
work,  reproduce  and  die.from the American Heart Association for the
prevention of coronary heart disease as well
Normally, our cells remain healthy. Sometimesas for general health promotion, as defined
a cell's instructions get mixed up and itby the Department of Health and Human
behaves abnormally. After a while, groups ofServices' 2000 Dietary Guidelines for
abnormal cells can circulate in the blood orAmericans.
immune system, or they can form lumps or
tumours.In 2006 there will be an estimated 174,470
new cases of lung cancer and an estimated
Tumours can be either benign (non-cancerous)162,460  Americans will die from the disease.
or malignant (cancerous). Benign tumour cells
stay in one place in the body and are notThe American Cancer Society offers support
usually  life-threatening.and hope for people diagnosed with lung
cancer and their families as well as
Malignant tumour cells are able to invade theresources to help smokers quit 24 hours a
tissues around them and spread to other partsday, 7 days a week, including its own
of the body. Cancerous cells that spread toQuitline, which since its launch in May 2000
other parts of the body are calledhas provided services to more than 150,000
metastases. The first sign that a malignantcallers. For more information, call
tumour has spread is often swelling of nearby800-ACS-2345  or  visit
lymph nodes, but cancer can metastasize to
almost any part of the body. It is importantLung cancer chemoprevention - Why does it not
to find malignant tumours early and treatwork?From  the  National  Cancer  Center.
them.
Common wisdom is that vitamin in fruits and
Cancers are named after the part of the bodyvegetables prevent cancer. However, trials of
where they start. For example, cancer thatsupplementing vitamins like vitamin A
starts in the colon but spreads to the liveranalogues (retinoids: beta-carotene, retinol,
is called colon cancer with liver metastases.retinyl palmitate, or isotretinoin) or
vitamin E (alpha-tocopherol), did not prevent
There are four main types of lung cancer:lung cancer in smokers. Randomised trials in
small cell lung cancer, squamous cellall the three settings: primary (healthy
carcinoma, large cell carcinoma andhigh-risk e.g. smokers), secondary
adenocarcinoma. Tobacco smoking is strongly(pre-malignant lesions), and tertiary
linked to the first three but only weakly(prevention of second primary tumours in
linked to adenocarcinoma. However, this typepreviously treated patients), have produced
of lung cancer has been linked to the use ofnegative results (either neutral or harmful).
low-tar  cigarettes.
Chemoprevention trials were prompted by
The best means of prevention is to neverrelationship between diet and lung cancer.
start smoking or using chewing tobacco, or toDiet rich in foliage vitamins was protective
stop using tobacco products. A healthy dietagainst lung cancer - as demonstrated in a
is  an  important  part  of  prevention.recent Dutch study of 939 patients.
Similarly, higher blood level of
The outlook varies by cell type and stage ofß-carotene is linked to a lower risk of
the disease. In general, the prognosis islung cancer. Nonetheless, intervention trials
better for squamous cell cancers than forfailed to show a reduced risk in lung cancer
adenocarcinomas. Early detection is key toby consuming ß-carotene. A phase III
better  chances  of  survival.trial, the Alpha-Tocopherol, Beta-Carotene
(ATBC) [beta-carotene (20 mg/d),
According to the American Lung Association,alpha-tocopherol (50mg/d)] indicated
87 percent of lung cancer cases are caused bysignificant increases in lung cancer
smoking. Another 12 percent are linked toincidence (18%) and no effect on lung cancer
radon exposure. Only 15 percent of peoplemortality  (risk  ratio,  0.99).
diagnosed with the disease will still be
alive five years after the diagnosis; 60Another study, CARET, had a 28% increase in
percent die within the first year. What islung cancer with vitamin treatment.
Chemoprevention? For individuals whoSimilarly, in both Euro-scan and the US-Lung
demonstrate the greatest risk, researchersIntergroup Trial (both testing retinoids in
are currently conducting several new trialstertiary  prevention),  results were neutral.
to test the use of natural and synthetic
substances to prevent development of theDisclaimer: please. Any information is for
disease. This new research has been coined,general entertainment and educational
chemoprevention.purposes only, and should not be construed as
medical advice, medical opinion, diagnosis or
The National Cancer Institute's (NCI)treatment. Any information provided by this
chemoprevention research effort started inweb site is not a substitute for actual
the early 1980s and has grown considerablymedical attention. Always promptly consult
since that time. Currently, approximately 400your licensed health-care professional for
compounds are being studied as potentialmedical advice and treatment.
chemopreventive agents, mainly in laboratory



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