| Human umbilical cord blood cells have
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| | therapies. Recently, it has been reported
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| many advantages as grafts for cell
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| | that umbilical cord blood contains
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| transplantation mainly because of the
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| | mesenchymal progenitor cells capable of
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| immaturity of the newborn cells in
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| | differentiating into marrow stroma, bone,
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| comparison with adult cells.
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| | cartilage, muscle, and connective
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| In contrast to their hematopoietic and
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| | tissues.
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| mesenchymal potential, it remains unclear
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| | Furthermore, umbilical cord blood
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| whether umbilical cord blood cells have
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| | provides no ethical problems for basic
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| endodermal competence.
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| | suties and clinical applications.
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| Umbilical cord blood contains circulating
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| | Umbilical cord blood cells can be
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| stem/progenitor cells, and the cellular
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| | collected without any harm to the newborn
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| contents of umbilical cord blood are
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| | infant, and umbilical cord blood
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| known to be quite distinct from those of
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| | hematopoietic stem cell grafts can be
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| bone marrow and adult peripheral blood.
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| | cryopreserved and transplanted to a host
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| Over the past two decades, the presence
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| | after thawing without losing their
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| and characteristics of hematopoietic stem
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| | repopulating ability. For these reasons,
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| cells in umbilical cord blood have been
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| | umbilical cord blood could be a prominent
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| clarified. The frequency of umbilical
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| | source of cells for transplantation in
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| cord blood hematopoietic stem/progenitor
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| | various diseases. It remains obscure,
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| cells equals or exceeds that of bone
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| | however, whether umbilical cord blood
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| marrow and greatly surpasses that of
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| | contains stem/progenitor cells leading to
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| adult peripheral blood. Compared with
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| | endodermal cells, including hepatocytes.
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| adult cells, umbilical cord blood
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| | Human umbilical cord blood cells can
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| hematopoietic stem cells produce larger
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| | proliferate hepatocyte lineage cells in
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| hematopoietic colonies in vitro, have
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| | the original primary culture system in
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| different growth factor requirements, are
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| | vitro, and differentiate into
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| able to expand in long-term culture in
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| | functionally mature hepatocytes in vivo.
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| vitro, and have longer telomeres.
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| | To our knowledge, this is the first
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| Umbilical cord blood transplantation for
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| | evidence that human umbilical cord blood
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| various hematopoietic reconstitutions and
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| | contains cells that produce
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| a lower incidence of graft-versus-host
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| | endoderm-proliferating cells.
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| disease than expected with conventional
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